Citicoline sodium (C14H25N4NaO11P2) is composed of ribose, cytosine, phosphoric acid and choline. As an endogenous compound of human body, Citicoline sodium is an important medium for phospholipid synthesis in cell membrane, and also an external source for synthesis of acetylcholine. Acetylcholine is an important neurotransmitter and plays a very important role in nucleotide metabolism.
Cerebral infarction, also known as ischemic stroke, refers to a clinical syndrome of cerebral blood supply disorders caused by cerebrovascular diseases of various causes, resulting in local brain tissue hypoxia, ischemic necrosis, and rapid emergence of corresponding neurological deficits.
【 R&D History 】
① In 1956, Geiger found in animal experiments that citicoline sodium could restore brain injury.
②Its molecular structure was determined by Kennedy in 1957 and has been shown to be essential in the synthesis of cephalin.
③ In 1961, Takeda Pharmaceutical Company of Japan developed and produced this product.
④ It was successfully developed in 1983 and approved for production in 1984.
China Pharmacopoeia 2020 edition II
Baolindanjianna
Chemical structure formula:
This product is a monosodium salt of choline cytidine nucleoside diphosphate, and contains not less than 98.0% of cytidine choline sodium (C14H25N4NaO11P2) according to the calculation of dried products.
【 Properties 】 This product is white crystal or crystalline powder; No odor.
【 Class】 Cell metabolism improving drugs.
【 Storage 】 Dark, sealed storage.
【 Preparations】 (1) Citicoline Sodium tablets, (2) CDPC injection, (3) Citicoline sodium glucose injection, (4) Citicoline sodium sodium chloride injection, (5) CDPC for injection, (6) Cyticoline sodium inosine for injection.
【 Pharmacological action 】
Citicoline can promote brain cell respiration, improve brain function, enhance the function of ascending reticular activation system, promote wake up, reduce cerebrovascular resistance, improve motor paralysis and cerebral blood circulation, promote cerebral substance metabolism, and play a certain role in promoting the recovery of brain function.
【 Citicoline sodium capsule instruction manual 】
Please read the instructions carefully and use under the guidance of a physician
【 Drug name 】
Common name: Citicoline sodium capsule
【Ingredients】 The main ingredient of this product is citicoline choline sodium, its chemical name is: choline cytosine nucleoside diphosphate monosodium salt.
Chemical structure formula:
Molecular formula :C14H25N4NaO11P2
Molecular weight :510.31
【 Properties 】 The content of this product is white particles.
【Indication】 It is used to treat the sequelae of the nervous system caused by craniocerebral injury or cerebrovascular accident.
【 Specification 】0.1g
【 Usage and Dosage 】 Take 1~2 capsules three times a day with warm water.
【Adverse reactions】 Occasional gastrointestinal reactions, mild, short duration.
【 Contraindication 】 Do not use this product with meclofenoxate (chloroxamate) drugs.
【Precautions】 Please read the instructions carefully before using this product; Use as directed by your doctor.
【Medication for pregnant and lactating women】 There is no data on the use of pregnant and lactating women.
【 Children’s medication 】 should follow the doctor’s advice.
【Geriatric medicine】 This experiment not conducted and no reliable references were available.
【 Drug interaction 】 So far, no interactions between this product and other drugs have found.
【Drug overdose】 No overdose symptoms have reported to date.
【Pharmacology and Toxicology】 This experiment not performed and no reliable references were available.
【Pharmacokinetics】 This experiment not performed and no reliable references were available.
【 Storage 】 Dark, sealed storage.
【 Packaging 】 Aluminum plastic packaging, 12 capsules/box; 14 capsules/box; 24 capsules/box; 28 capsules/box; 42 capsules/box.
【Validity】 36 months.
【Executive Standard】 WS,-(X-002)-2014Z
