Glutathione is also known as a great discovery. It was discovered by an Englishman who was also under great stress.
At the same time as Fleming, his name was Frederick Goland Hopkins, and his name is too long, let’s call it Hopkins.
Glutathione was discovered before penicillin in 1921.
Hopkins was very successful all his life. How did he succeed?
Is the Nobel Prize title enough?
He won the Nobel Prize for discovering multivitamins with a friend.
Unlike penicillin, glutathione found in the human body and a substance that is naturally present in the body.
The amount of glutathione in the body is highest during infancy, and gradually decreases with age.
In nature, it mainly found in yeast, animal liver, muscle and blood cells.
Some plants also contain high levels of glutathione, such as tomatoes.
What is glutathione?
Glutathione composed of glutamic acid, cysteine, glycine, containing a hydrophobic tripeptide, referred to as GSH, which is the combined name of Glutathione + sulfhydryl SH.
And some whitening substances, such as transomic acid, in the early clinical stage mainly used for non-whitening effects, glutathione in the clinical core role of detoxification, so in the purification of internal organs has a significant role,
such as repairing liver and kidney and other organs damaged, eliminate heavy metals in the body.
Subsequently, it found that GSH has the role of whitening skin and improving skin quality.
As for glutathione exactly how to achieve the above two purposes.
Let’s start with how human skin ages and darkens.
How are free radicals created?
Under normal circumstances, our body can balance free radicals this little troublemaker, but with the deterioration of the surrounding environment of life, plus staying up late, drinking, smoking, and constant pressure.
The free radicals in the human body become more and more, the more electrons to rob, the more electrons to lose the other half began to go wild, become extremely unstable, revenge corruption.
As a result, it leaves one after another on your face, patches, etc., and makes your face begin to wrinkle and become slack and dull.
How does glutathione whiten?
In our human body, there are some free radical scavenging, antioxidant substances, including superoxide dismutase (SOD), catalase, glutathione peroxidase and some other enzymes and vitamin C, vitamin E, reduced glutathione (GSH), carotene and active selenium, these substances are also the main components of some anti-aging products.
Among them, GSH plays an important role in the biochemical defense system of the human body and has many physiological functions.
Its main physiological role is to remove free radicals in the human body, as an important antioxidant in the body, to protect many proteins and enzymes and other molecules in sulfhydryl.
In addition, the structure of GSH contains a lively sulfhydryl -SH, which easily dehydrogenated by oxidation, and this specific structure makes it the most important free radical scavenger in the body.
Glutathione can purify the body environment, eliminate free radicals, and delay skin aging.
So how does glutathione work?
Because the amount of melanin synthesis positively correlated with tyrosinase activity, blocking tyrosinase is the key to prevent black.
The ingredients that can inhibit tyrosinase activity include glutathione, tranexamic acid, hydroquinone, arbutin, etc. The mechanism of action is slightly different.
The cysteine in GSH has such functions, and it has found in medical trials that cysteine can reduce tyrosinase activity.
Cysteine is an amino acid containing sulfhydryl group, which has a strong nucleophilic effect. Sulfhydryl group can react quickly with dopa quinone to quickly form colorless dopa derivatives, thus blocking the conversion of dopa to pigment.
Glutathione does interfere with melanin synthesis, mainly through the following mechanisms:
1, directly inhibit tyrosinase activity.
2, Free radicals can activate tyrosinase, while glutathione can remove free radicals and inhibit the activation of tyrosinase.
3, Tilt the melanin synthesis pathway toward phaeomelanin (rather than melanin, which darkens the skin).
The main role of glutathione
Whitening freckle, inhibiting melanin formation;
The mother of antioxidant, has the function of protecting liver cells and promoting liver enzyme activity;
Liver protection and detoxification, anti-allergy, anti-cancer, anti-radiation hazards, etc.
Blackening is mainly due to the continuous increase of free radicals in the human body and the continuous oxidation of the skin.
Glutathione can effectively resist skin oxidation, transform the body’s free radicals, and form a natural anti-black barrier in the body. It recognized as a medical grade whitening ingredient.
