What is NMN? What does NMN do?
NMN is an inherent substance in the human body, also rich in some fruits and vegetables, it is widely involved in a number of biochemical reactions in the human body, is also the composition of NAD+ (nicotinamide adenine dinucleotide) raw material.
By supplementing NMN to improve the level of NAD+ in the body, so as to combat aging, that is to say, the function of NMN is mainly reflected by NAD+.
What does NAD+ have to do with aging?
To put it simply, NAD+ and aging are like fighting guerrilla warfare: you advance, I retreat, you retreat, I advance.
People with low NAD+ levels will become aging, and increasing NAD+ levels will delay aging.
Because of this, targeting the NAD+ metabolic pathway to increase NAD+ levels may be a potential means to improve age-related diseases and extend human lifespan and healthy lifespan.
How to supplement NMN daily?
Since NAD+ cannot absorbed orally, the level of NAD+ in the body can only increased by supplementing NAD+ precursor NMN.
There are two ways to supplement NMN in your daily life:
1. Food source
NMN widely distributed in everyday foods and occurs naturally in a variety of foods:
The NMN content in vegetables and fruits ranges from 0.25-1.88 mg /100 g, while raw beef and raw shrimp have relatively lower NMN content than plant foods (0.06-0.42 mg /100 g).
2. NMN supplement
There are many kinds of NAD+ precursors, of which NMN is the most direct precursor of NAD+, which is directly converted to NAD+ by the enzyme NMNAT.
Attention!
- The pharmacokinetics and metabolic mechanisms of NMN are still being studied, and not all cells can convert all NAD+ precursors to NAD+. Moreover, the degree of absorption and utilization of NAD+ precursors is also different in different tissues and organs.
- Regarding the side effects of NMN, studies have pointed out that doses as high as 1250mg/ day of NMN do not cause any adverse side effects or harm health.
Although NMN currently a commonly used product with anti-aging effect, if taken for a long time, the effective effect of NMN anti-aging should understood from a scientific point of view, and used under the guidance of professionals.
References:
- 1、Song, Q, et al., （2023). The Safety and Anti-Ageing Effects of Nicotinamide Mononucleotide in Human Clinical Trials: An Update. Advances in Nutrition.
- 2、Nadeeshani, H., Li, J., Ying, T., Zhang, B., & Lu, J. （2022). Nicotinamide mononucleotide （NMN) as an anti-aging health product–promises and safety concerns. Journal of advanced research, 37, 267-278.
- 3、Fukamizu Y, et al., Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult people of all genders. Sci Rep. 2022;12:14442. doi:10.1038/s41598-022-18272-y.
