The king of antioxidants, glutathione

Glutathione is the king of antioxidants

Glutathione’s amazing bioactive tripeptide Glutathione (GSH) is a bioactive tripeptide made from the dehydrated condensation of L-glutamic acid, glycine, and L-cysteine by peptide bonding. First discovered by Hopkins in 1921, glutathione contains a large number of gamma-glutamyl and sulfhydryl bioactive groups. Reduced form (GSH) and oxidized form (GSSG) are the two forms of glutathione that…

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Cell metabolism

Fat cells secrete glutathione to promote breast cancer

yesterday, Ke Li and Zhuorong Li, Institute of Medical Biotechnology, Chinese Academy of Medical Sciences, jointly published a paper “Adipocyte-derived glutathione promotes obesity-related breast cancer by Cell metabolism” regulating the SCARB2-ARF1-mTORC1 complex “, which discovered the role of glutathione (GSH) in obesity-related breast cancer. Obesity is an important risk factor for breast cancer, however the…

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Engineering Escherichia coli for efficient glutathione production

Modified Escherichia coli produced record glutathione

What is glutathione? Glutathione (GSH) is a tripeptide composed of glutamic acid, cysteine and glycine that has a wide range of applications in the pharmaceutical, food and cosmetic industries. At present, traditional industrial production methods mainly rely on yeast fermentation process to synthesize, but this process has some limitations, glutathione will accumulate in yeast cells,…

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Health benefits of glutathione

Health benefits of glutathione

Glutathione is an active tripeptide formed by the condensation of glutamic acid, cysteine and glycine by peptide bond. GSH is widely found in animal liver, blood, yeast and wheat germ, and a small amount is also distributed in plant tissues such as vegetables. Glutathione has unique physiological functions and is known as longevity factor and…

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The glutathione S-transferase Gsttl drive ssurvival and dissemination in metastases

Novel mechanism of tumor metastasis mediated by glutathione S-transferase Gstt1

Recently, Raul Mostoslavsky’s team, from Harvard Medical School in The US, published a paper online in Nature Cell Biology entitled “The glutathione S-transferase Gstt1 drives survival and Survival” dissemination in metastases is to carry out RNA sequencing (RNA-SEQ) and subsequent lost-function shRNA targeting for matched primary and metastatic solid tumors from PDAC and breast cancer…

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Autoregulatory control of mitochondrial glutathione homeostasis

Feedback regulation mechanism of glutathione balance in mitochondria

Glutathione is an important antioxidant in cells and plays an important role in cellular iron metabolism and detoxification of allogenic substances. Metabolic processes in cells are constantly influenced by various environmental factors. Many small metabolites (such as amino acids, certain coenzymes, and metal ions) need to be maintained at appropriate physiological concentrations to ensure normal…

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Glutathione

The antioxidant glutathione

Glutathione is an important antioxidant in the human body, in the form of reduced glutathione (GSH) and oxidized glutathione (GSSG), of which GSH is composed of glutamic acid, glycine and cysteine through peptide bonding, and is synthesized in the liver in the largest amount. Glutathione has many physiological functions 1, Antioxidant effect Free radicals can…

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