As a new anti-aging molecule, NMN (β-nicotinamide mononucleotide) has become a new star in the field of anti-aging.
A research team from Doshisha University in Japan announced the results of a clinical study on the effect of NMN (β-nicotinamide mononucleotide) on the health of postmenopausal women at the 22nd Japanese Society of Anti-Aging Medicine Conference, revealing the significant effect of NMN in improving the metabolism, hormone balance and skin aging of this specific population.
Research overview
The study recruited 17 healthy postmenopausal women with an average age of 55 years to take 300 mg of pure NMN every morning for eight weeks while maintaining their lifestyle, and 16 of them successfully completed the study.
Key finding
1. NMN increases adiponectin and DHEA-s levels
Adiponectin:
The results of the study showed that after taking NMN, participants’ adiponectin levels increased significantly from 13.6 MCG/ml to 16.2 MCG/ml.
Adiponectin, as an important endocrine factor, is not only involved in the regulation of glucose and lipid metabolism, energy consumption, inflammation and other physiological processes, but also promotes bone health.
DHEA-s (Dehydroepiandrosterone sulfate) :
Participants’ DHEA-s levels also increased from 1,108 ng/ml to 1,275 ng/ml.
DHEA-s is a key hormone that has multiple benefits for human health, including increased vitality, improved memory, and lower cholesterol levels, and its secretion gradually decreases with age.
2. NMN improves skin aging indicators
AGEs (Advanced glycation End Products) :
After taking NMN, the number of AGEs in participants’ skin decreased significantly, and AF values dropped from 2.43 to 2.35.
AGEs are compounds formed when sugars and proteins combine to accelerate aging and cause a variety of chronic diseases.
Visual simulation score:
Of the seven items assessed for skin changes, six showed significant improvements, including moisture, dry skin, age spots, and skin elasticity.
Multiple health benefits of NMN
1. Regulates hormone balance and activates Sirtuins proteins
By increasing NAD+ (nicotinamide adenine dinucleotide) levels, NMN activates proteins such as SIRT1 in the Sirtuins family, which play a key role in cell metabolism regulation and gene expression, helping to maintain hormone homeostasis.
2. Promote mitochondrial function
Mitochondria are the center of cell energy production, and their abnormal function can affect many physiological processes.
NMN indirectly supports the normal functioning of the endocrine system by enhancing mitochondrial function.
3. Protect cardiovascular health
- Lower inflammatory response: NMN inhibits the production of pro-inflammatory factors and reduces chronic low-grade inflammation, which is essential for heart health.
- Protect the vascular endothelium: strengthen the antioxidant defense system, reduce the damage of oxidative stress to the vascular wall, maintain vascular elasticity and blood flow.
- Regulating lipid metabolism: Affects fatty acid oxidation pathways, helps control cholesterol levels and reduces the risk of atherosclerosis.
4. Increase bone density and muscle mass
Stimulate the activity of osteoblasts: promote the differentiation and mineralization of osteoblasts, increase the rate of new bone formation, and combat bone loss.
Prevent muscle atrophy: Improve the energy utilization efficiency of muscle cells, delay muscle strength decline, and enhance daily activities.
5. Improve aging and lengthen telomere length
Supplementation with NMN can effectively reverse the decline in NAD+ levels, thereby improving multiple cellular functions.
For example, improving mitochondrial function, promoting the production of ATP, and improving the energy supply of cells;
Promote DNA repair and reduce telomere loss; Activate telomerase and delay telomere shortening.
Together, these effects support the healthy division and regeneration of cells, providing a new approach to anti-aging.
Understanding aging is the only way to delay aging
As an emerging anti-aging molecule, NMN has shown great potential in the health management of postmenopausal women.
By regulating hormone balance, promoting mitochondrial function, protecting cardiovascular health, enhancing bone density and muscle mass, and improving skin aging, NMN is gradually becoming a powerful tool to improve the health of menopausal women.
Understanding and clearing their own aging state, and on the basis of scientific anti-aging, is the essence of anti-aging.
NMN has the effect of protecting and lengthening telomeres, and telomeres are the “weather vane” of the human aging state.
Each time a cell divides, the telomeres shorten a bit due to the direction constraints when DNA replicates.
With the deepening of telomere research, there are detection services based on telomere length to help people scientifically assess their aging state.
These services typically use PCR (polymerase chain reaction) or FISH (quantitative fluorescence in situ hybridization) techniques to assess an individual’s degree of aging by measuring telomere length in oral epithelial cells.
