Blood vessel problems often cause heart problems, and the heart is the engine of the human body, NMN
once the heart is threatened, human health will face great risks.
So, how can we effectively prevent vascular and heart disease?
In addition to the reasonable arrangement of daily diet and daily life, but also through NMN supplements,
scientific studies have revealed that NAD+ plays an important role in preventing and improving cardiovascular diseases. NMN Factory
A review article published in Clinica Chimica Acta by Dr. Qiming Liu, Director of the Department of Cardiovascular Medicine at the Second Xiangya Hospital of Central South University,
highlights the importance of NAD+ in the treatment and prevention of cardiovascular diseases.
He clearly pointed out that supplementing and stabilizing the level of NAD+ in the human body is one of the current excellent programs for the treatment and even prevention of cardiovascular disease.
And the best prerequisite for NAD+ is NMN.
1. NMN improves the aging of vascular smooth muscle
The study by Hongbo Xin (Nanchang University), Jianxin Xue and Lu Gan (West China Hospital of Sichuan University) shows that the decrease of intracellular NAD+ level caused by CD38 (a key link in NAD+ metabolism) is a key cause of cerebrovascular disease in old age people.
In addition, NMN supplementation can inhibit CD38 and effectively increase the level of NAD+,
thus delaying the aging of vascular smooth muscle cells in mice and reducing pathological structural changes,
which has a positive effect on hypertension and vascular structural abnormalities.
2. NMN can prevent cardiomyopathy
Research from the School of Life Sciences of Fudan University has revealed the importance of short-chain enoyl-CoA hydratase 1 (ECHS1) in the development of cardiomyopathy.
Lack of ECHS1 may lead to the imbalance of histone acetylation in cardiac fibroblasts, and NMN expected to prevent the development of ECHS1-deficient cardiomyopathy by mediating histone acetylation,
providing a new possibility for the prevention of cardiomyopathy.
3. NMN accelerates the repair of cardiovascular diseases
Professor Ge Junbo (Academician of the Chinese Academy of Sciences and Zhongshan Hospital of Fudan University) and his team discovered that NAD+ involved in cardiovascular disease signaling pathways and has the potential to repair cardiovascular disease by regulating metabolism,
maintaining REDOX homeostasis and immune response.
NMN, as a precursor to NAD+, also has these benefits and can delay aging through multiple molecular pathways,
thereby intervening in the process of cardiovascular disease.
4. NMN helps fight atherosclerosis
A study by the School of Biological Sciences of the Chinese University of Hong Kong found that the loss of the NAD+ dependent mitochondrial deacetylase SIRT3 promotes atherosclerosis.
However, treatment with NAD+ precursors can reduce the formation of plaques in blood vessels,
improve blood vessel function and reduce blood vessel inflammation.
5. NMN helps maintain heart health
A study from the Case Cardiovascular Institute and Case Western Reserve University in the United States explored the relationship between NAD+ and heart failure from the perspective of mitochondrial function,
and they found that moderate intake of NMN can increase NAD+ levels, help protect mitochondrial function,
thereby maintaining heart health, and reduce the risk of heart failure and cardiomyopathy.
6. NMN helps prevent and treat heart failure in the old age
An editorial published in the journal Nature Cardiovascular Diseases summarizes the significance of NAD+ supplementation in the treatment of age-related heart failure.
The article points out that promoting NAD+ metabolism by supplementing precursors such as NMN may be an effective treatment for heart failure,
helping to reduce the number of hospitalizations for cardiovascular disease in the old age and reduce the risk of cardiac death.
7. NMN reduces oxidative stress of cardiomyocytes
Heart muscle cell death is a cause of many serious heart diseases,
and mesenchymal stem cells have the ability to generate new heart muscle cells.
Professor Wenlong Zhang and his team at Zhengzhou University found that pretreating mesenchymal stem cells with NMN can improve their survival and reduce the oxidative stress response of cardiomyocytes,
thereby enhancing the therapeutic effectiveness of myocardial infarction.
The role of NMN in cardiovascular cannot ignored!
