Glutathione

The antioxidant glutathione

Glutathione is an important antioxidant in the human body, in the form of reduced glutathione (GSH) and oxidized glutathione (GSSG), of which GSH is composed of glutamic acid, glycine and cysteine through peptide bonding, and is synthesized in the liver in the largest amount. Glutathione has many physiological functions 1, Antioxidant effect Free radicals can…

Read More
Activation of glutathione metabolism through mitochondrial autophagy promotes hair regeneration

Activation of glutathione metabolism through mitochondrial autophagy promotes hair regeneration

On August 1, 2024, Professor Lei Mingxing team of Chongqing University published a comprehensive TOP journal Research (District 1, Chinese Academy of Sciences, IF=11) publish an article entitled Mitophagy Promotes Hair Regeneration by Activating Glutathione Metabolism, It was found that mitochondrial autophagy promoted the proliferation of hair embryo (HG) cells by regulating glutathione (GSH) metabolism….

Read More
Modified Escherichia coli produced record glutathione

Modified Escherichia coli produced record glutathione

Glutathione (GSH) is a tripeptide composed of glutamic acid, cysteine and glycine that has a wide range of applications in the pharmaceutical, food and cosmetic industries. At present, traditional industrial production methods mainly rely on yeast fermentation process to synthesize, but this process has some limitations, GSH will accumulate in yeast cells, and the extraction…

Read More
Glutathione precursors are a potential treatment for mental stress

Glutathione precursors are a potential treatment for mental stress

How to treat stress-related psychological disorders has always been an important research topic in the field of life science. Recently, an authoritative study revealed the role of glutathione precursors in the treatment of stress-related mental disorders. Chronic stress not only increases the risk of psychological disorders such as anxiety and depression, but is also a…

Read More

Glutathione precursors are a potential treatment for mental stress

An authoritative study has revealed the therapeutic role of glutathione precursors in stress-related mental disorders. Chronic stress not only increases the risk of psychological disorders such as anxiety and depression, but is also a risk factor for neurodegenerative diseases (e.g., Parkinson’s disease, Alzheimer’s disease), metabolic disorders (e.g., large waist circumference, high blood pressure, diabetes), and…

Read More
glutathione

Engineered E. coli to produce glutathione efficiently

Key research points Glutathione is an important tripeptide that is widely used in the pharmaceutical, food and cosmetic industries. In this paper, metabolic engineering of Escherichia coli (E. coli) was used to produce glutathione efficiently. Conventional glutathione is mainly produced by yeast fermentation, but the intracellular accumulation of yeast limits its production. The researchers significantly…

Read More
Glutathione

Glutathione promotes T cell metabolism, which leads to inflammation

abstract Activated T cells produce reactive oxygen species (ROS), which trigger the antioxidant glutathione (GSH) response, which is essential for buffering elevated ROS and preventing cell damage. We report that glutathione is essential for T cell effector function by regulating metabolic activity. Conditional gene knockout of the catalytic subunit of glutamate-cysteine ligase (Gclc) blocks glutathione…

Read More