What is the result of taking 2000mg of NMN daily for 28 days?

Nicotinamide Adenine Dinucleotide Augmentation in Overweight or Obese Middle-Aged and Older Adults: APhysiologic Study

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  • Taking 2000 mg of NMN daily for 28 days can reduce the weight of higher weight or person in higher weight body middle-aged and older people.
  • NMN can lower total blood cholesterol, including low-density lipoprotein (LDL) cholesterol, which is associated with the buildup of blood vessel cholesterol.
  • NMN reduces diastolic blood pressure, indicating that blood pressure can be lowered.

The team at Harvard Medical School published their findings in The Journal of Clinical Endocrinology & Metabolism.

The study focused on higher weight or person in higher weight body adults over 45 years of age and looked at the effect on body weight by taking 2,000 mg of NMN daily for 28 consecutive days.

Participants who received β-Nicotinamide Mononucleotide lost significantly more weight than participants who did not receive NMN.

Specifically, some studies showed weight loss of more than 6 pounds (about 2.7kg),

suggesting that NMN supplementation has a positive effect on promoting metabolic function and weight loss.

NMN is Lower total cholesterol

Not only does β-Nicotinamide Mononucleotide reduce total cholesterol levels, it also specifically targets low-density lipoprotein (LDL) cholesterol, commonly known as the “bad cholesterol,” which strongly linked to the buildup of cholesterol in blood vessels and a significant contributor to heart-related problems.

Figure: NMN lost weight in higher weight or person in higher weight body (β-Nicotinamide Mononucleotide group in blue, control group in red)
Image: NMN (blue) lowers cholesterol

By examining blood cholesterol levels, the researchers found that supplementing with β-Nicotinamide Mononucleotide significantly reduced total cholesterol and LDL cholesterol levels, resulting in a positive impact on cardiovascular health.

Mechanism of action of NMN

Enhance mitochondrial function:

As a precursor of nicotinamide adenine dinucleotide (NAD+), NMN can increase intracellular NAD+ levels,

thereby enhancing mitochondrial function, improving energy production efficiency, and helping to reduce fat accumulation.

Activate AMPK channel:

AMPK an energy receptor within cells that activated when cellular energy levels drop.

Activated AMPK promotes processes such as fatty acid oxidation, glucose uptake and mitochondrial biogenesis,

thereby increasing energy expenditure and helping to control body weight.

Improve insulin sensitivity:

By increasing the level of NAD+, NMN activates SIRT1 and other deacetylases,

improves insulin sensitivity, promotes lipolysis and reduces fat synthesis.

Regulating leptin and adiponectin levels:

Leptin and adiponectin hormones secreted by adipocytes, which play an important role in regulating appetite and energy metabolism.

Nicotinamide Mononucleotide regulates the levels of these hormones and improves appetite and energy metabolism.

GSH Bio-Tech company main products L-glutathione reduced (GSH), β-Nicotinamide Mononucleotide , Citicoline Sodium (CDPC) and other raw materials.

The acid market share ranks among the top three in China, and the products are exported to Europe, America, South Korea, India and other parts of the world.