Citicoline sodium (CDPC-Na) is the sodium salt form of citicoline. Citicoline is a natural metabolite that exists in trace amounts in every living cell and plays an important role in the synthesis of cellular phospholipids. crucial role.
Exogenous citicoline has neuroprotective effects and indicated for the treatment of a variety of chronic and acute neurological disorders (e.g., Parkinson’s disease, stroke, brain and spinal cord injuries, glaucoma). Citicoline also considered a memory enhancer in the United States and the European Union.
Pharmacological effects of citicoline sodium
When ingested, citicoline well absorbed and rapidly broken down into choline and cytidine. This results in a significant increase in blood choline levels, and blood cytidine rapidly converted to uridine. Next, choline and uridine enter the body’s cells and join their appropriate metabolic pathways.
- 1. Promote energy metabolism of brain tissue
CDPC promotes phospholipid synthesis in the brain and repairs cell membrane structure; Citicoline inhibits the activity of phospholipase, reduces the decomposition of phospholipids, and blocks cell apoptosis.
- 2. Stimulate neurotransmitter system
Citicoline promotes striatal dopamine synthesis; Citicoline effectively protects dopaminergic neurons.
- 3. Promote energy metabolism of brain tissue
Citicoline restores the activity of Na-K-ATPase; Citicoline promotes energy metabolism in the brain.
Neuroprotective effects of citicoline sodium
The citicoline cycle integrated into various metabolic pathways, and its disruption can affect the distribution of various lipid metabolites. Citicoline also involved in the metabolism of acetylcholine, and its administration represents a source of exogenous supply of choline and cytidine.
Choline involved in many relevant neurochemical processes, is a precursor and metabolite of acetylcholine, plays an important role in carbon metabolism, and is an important component of different membrane phospholipids. Once converted to uridine, the cytidine moiety can used for DNA and RNA synthesis, as well as the synthesis and glycosylation of various membrane components.
- 1. Affects intrasynaptic neurotransmitter levels
Increases central nervous system dopamine, norepinephrine, and acetylcholine levels.
- 2. Promote the repair and regeneration of nerve cell membranes
Choline is an intermediate in the synthesis of phosphatidylcholine, and phosphatidylcholine can stimulate the repair and regeneration of damaged neuron cell membranes and promote the recovery of neurological functions.
- 3. Reduce the toxic effects of excitatory amino acids
Reduce extracellular glutamate levels and alleviate the toxic effects of excitatory amino acids.
- 4. Promote brain energy metabolism
Restore the activity of Na-K-ATPase and restore abnormal neuronal ATP levels.
- 5. Anti-inflammatory, antioxidant effects
Citicoline reduces phospholipase A2 (PLA2) activity, reducing inflammation and free radical production.
- 1. What is the difference between Citicoline and Citicoline Sodium?
Citicoline sodium is the sodium salt form of citicoline, and dietary supplement forms of citicoline are usually in the sodium form for absorption.
- 2. What are the ways of ingesting Citicoline Sodium?
The administration routes of Citicoline include oral administration, intravenous drip and intramuscular injection. Oral administration can actually completely absorbed because bioavailability almost the same as that intravenous administration. Once Citicoline absorbed, It can widely distributed in various parts of the body and can cross the blood-brain barrier and enter the central nervous system.
- 3. Is Citicoline Sodium Good for Eyes?
Many studies suggest that citicoline may play a role in treating neurodegenerative diseases. Specifically, citicoline oral solution and eye drops have been found in clinical trials to slow the progression of glaucoma as an add-on therapy for the treatment of glaucoma.
- 4. Is Citicoline Safe?
Long-term treatment with citicoline was shown to be well tolerated and not associated with serious adverse events. In a safety study conducted in South Korea, the drug’s safety profile was rated as excellent as only 37 adverse reactions were reported out of 4,191 treated cases.
- 5. CWhat should I avoid while taking citicoline sodium?
Interactions between Citicoline Sodium and Food and Beverages: Limit alcohol consumption and smoking as these substances can reduce the effect and affect the health of the body.
- 6. Does Citicoline Sodium Have Any Effects on Healthy People?
Recent studies have found that citicoline has positive effects on healthy people. Research has proven that the use of citicoline has a positive effect on compensating autonomic nervous system and frailty disorders, improving cognitive status, and correcting psychological and emotional disorders in college students and teachers.
Another study demonstrated that citicoline improved overall memory performance, particularly episodic memory, in healthy human beings with age-related memory impairment.
According to currently available scientific reports, citicoline is considered a safe and useful substance suitable for many indications and is also characterized by the absence of serious side effects and very good efficacy.
Of course, always consult your healthcare provider for a diagnosis, accurate medical information, and clearance before taking any supplements.
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