NMN suitable for middle-aged and older people can effectively improve physiological function and metabolism
With the rapid development of medical technology and the continuous improvement of quality of life, population aging has become a common challenge facing the world.
The health status of middle-aged and older people people is not only related to the process of social development, but also has a profound impact on economic stability.
Therefore, exploring the secret of anti-aging has become a hot spot in the field of scientific research. In recent years, NMN, as a kind of anti-aging substance, has gradually entered people’s field of vision.
NMN, the elegant embodiment of vitamin B3, dances around the cell, subtly increasing the concentration of NAD+.
NAD+ acts as a cellular conductor, guiding the cell’s energy metabolism and repair mechanisms.
In this article, we will focus on the amazing benefits of NMN for middle-aged and older people and explore the mysteries behind it.
Years have left their marks on the bodies of middle-aged and older people, and their energy metabolism has gradually slowed down, as if it were a silent farewell.
However, studies have shown that the addition of NMN is like injecting new vitality into the cell, so that NAD+ is full of vitality.
As an intracellular energy messenger, NAD+ helps the oxidative phosphorylation process and promotes the production of ATP.
With the accompanment of NMN, the cells seem to return to youth, the energy source flows, and the metabolic state of middle-aged and older people also improved and full of new vitality.
After three years of NMN human trials, the elegant dancer of nicotinamide adenine dinucleotide (NAD+), NMN, with its unique charm, danced on the human stage without causing any adverse physiological ripples, which is undoubtedly the best proof of its safety.
On the stage of the trial, NMN showed a remarkable performance, which not only improved insulin sensitivity for the older people, but also injected them with a steady stream of vitality. NMN, the elegant precursor to NAD+, has been under scrutiny by the US Food and Drug Administration since November 2022.
However, under the fire of the review, NMN has not fully defined as a dietary supplement. Instead, it authorized for in-depth investigation as a new drug and has the subject of numerous public clinical investigations. This decision undoubtedly casts a veil of mystery over the future of NMN.
Although the sale of NMN not officially authorized under the scrutiny of the US Food and Drug Administration, the enthusiasm in the market has not quenched. Those who firmly believe in NMN may be looking forward to its efficacy and safety evaluation as an anti-aging supplement.
And those who have embarked on the journey of NMN trials are also quietly exploring its mysteries, hoping to bring new hope for human health and longevity.
Published in Advances in Nutrition Research, Yang and colleagues from Hangzhou Normal University in China reviewed the currently published human trials of NMN to take a closer look at its safety and effectiveness against physiological deterioration during aging.
Based on human trials, NMN appears to confer physical and metabolic benefits on the older people. Even so, it remains unknown whether many of the benefits of NMN against degeneration in older rodents apply to older adults, the researchers found.
An analysis of existing data from human trials of NMN reveals the promise of NMN as an anti-aging treatment, but suggests that human trial studies still have a long way to go before concluding whether the excessive benefits of NMN on aging in rodents apply to humans.
Existing human clinical trials have shown that oral NMN generally safe, and although the study indicators are limited, the results suggest that NMN has anti-aging potential.
As the years pass, our NAD+ levels gradually decrease, fading like a sunset.
The researchers gained insight into this phenomenon and speculated that boosting levels of precursors such as NMN might provide a line of defense for adults against age-related organ decline.
As a result, more and more people choosing to supplement NMN, and this group expected to continue to expand in the coming years, driving the global NMN market to grow steadily from 20% in 2014 to 20% in 2015.
It predicted that by 2027, the market size expected to reach $387 million, and by 2020, it likely to climb to $252.7 million.
Perhaps the most striking thing about this NMN craze, however, is not the prosperity of its market, but its safety. After all, in the pursuit of health, safety is always an indispensable cornerstone.
The first study to assess the safety of NMN came from Keio University in Japan in 2016, and the short-term study involved male participants ingestion of 100, 250, or 500 mg of NMN in the morning.
They were then monitored for five hours. The results showed that the drugs had no effect or change in blood pressure, heart rate, oxygen saturation or body temperature.
Based on their findings, the Keio University researchers concluded that up to 500 mg of NMN is safe and well tolerated.
GSHWORLD NMN adopts the extremely difficult fermentation method + biological enzyme method to imitate the working process of catalytic enzymes in human body to produce NMN, which is green and optimal, avoiding the residue of chemical extraction process and reducing the use effect.
The purity is 99.9%, the content is 32000mg, a bottle of 80 capsules, each capsule contains 400mg high,
and there is a wake-up factor, after entering the human body, the target locks the damaged gene source. It absorbed from the intestine into the blood circulation within 2-3 minutes, opens the energy channel in 4 minutes, rapidly activates the directed energizing,
supplements NAD+ in sufficient amount in 15 minutes, deeply repairs the damaged genes,
and prevents the aging of the cell, and transported to the tissue within 10-30 minutes.
GSHWORLD NMN is then immediately used for NAD + biosynthesis, significantly increasing the amount of NAD + in tissues within 60 minutes.
GSHWORLD NMN has a fine package of awakening agents to make up for the blind area of NMN repair,
open the whole body link, quickly update the iterative metabolic function,
continue to empower young genes, and resist the traces of age.
Since the Keio University study in 2016, seven other human trials have conducted to test safety parameters at different doses. In the Harvard study, the highest dose of oral NMN was 1,000 mg twice daily for 14 days with no side effects. These studies show that Nicotinamide Mononucleotide is safe, well tolerated and does not induce cancer.
(Song et al., Advances in Nutrition 2023) NAD+ levels in young individuals decline with age,
but supplementation with NAD+ precursor NMN increases blood NAD+ levels.
Rodent studies testing the anti-aging benefits of NMN have given some positive findings related to physical properties,
brain function and metabolism, as well as other physiological parameters.
Given the positive findings in rodents,
the researchers recently expanded their human trial to test whether NMN can improve age-related physical decline.
Along these lines, Igarashi and fellow researchers found that NMN improved muscle movement,
walking speed, left hand grip strength, and frequency of standing and sitting within 30 seconds in older adults.
Data from the study suggest that Nicotinamide Mononucleotide improves physical performance in older adults.
Another study measuring the effect of NMN on physical performance came from Liao and his colleagues,
who measured its effect on trained runners.
Nicotinamide Mononucleotide significantly improves a runner’s aerobic capacity,
which is measured by blood oxygen consumption (the amount of oxygen the body uses to produce energy).
In addition, a study by Professor Huang and colleagues showed that NMN promoted sustained improvements in walking endurance in adults aged 40 to 65 years, as measured by a 6-minute walking endurance test.
These findings suggest that Nicotinamide Mononucleotide enhances exercise capacity in middle-aged and older adults.
As we have shown, GSHWORLD NMN plays a crucial role in creating NAD +.
When we have high levels of NAD +, cellular energy increases, which becomes the engine of life,
powering every organ and cell in our body and protecting us from DNA damage.
NAD + also activates Sirtuins, which are essential for extending our lifespan and slowing down the aging process.
Supplementing with NMN can directly increase the level of NAD + in the body,
thus counteracting the natural decline that occurs with age.
Studies have shown that by supplementing with Nicotinamide Mononucleotide,
the level of NAD + in older adults can be increased by 20 years!
A cutting-edge study reveals that NMN has significant benefits for prediabetes in postmenopausal women who are person in higher weight body.
According to the study, Nicotinamide Mononucleotide effectively increased the participants’ muscle sensitivity to insulin by up to 25% and significantly improved the insulin signaling mechanism. This finding highlights the unique advantages of NMN in metabolic regulation, especially in women with prediabetes.
In addition, more authoritative evidence from human trials shows that Nicotinamide Mononucleotide has the potential to improve age-related hearing loss.
Along this line of research, Igarashi and his team found that older men’s right ear hearing improved significantly.
The ends of chromosomes (telomeres) shorten with age, and this shortening is a biological sign of aging. Niu and his colleagues therefore found that in men aged 40 to 60 years, supplementation with 300 mg of NMN per day almost doubled the telomere length of blood cells (peripheral blood mononuclear cells) during 90 days of treatment. These results suggest the anti-aging effects of NMN supplementation at the molecular level.
(Song et al., 2023 | Advances in Nutrition) Human trial results show that NMN is safe and has benefits for physical function,
insulin sensitivity, telomere length, and hearing during aging.
Some rodent studies have shown that Nicotinamide Mononucleotide improves brain, respiratory system, liver, heart, immune,
and reproductive function, but whether these benefits translate to humans remains to be determined.
In essence, more human trials are needed to determine whether Nicotinamide Mononucleotide has the same benefits in humans as it does in rodents.
The difference between GSHWORLD Nicotinamide Mononucleotide and NMN is that in addition to delaying aging function,
GSHWORLD NMN can stimulate dormant cells and reduce cell aging rate.
GSHWORLD NMN Level 4 booster:
Four essential amino acid protection technologies to enable the complete release of Nicotinamide Mononucleotide in the body
- Level 1 enhanced boost: converted to NAD+;
- Secondary reinforcement boost: promote the consumption of enzyme PARP;
- Three stages of strengthening and boosting: regulating Sirtuins fine pod longevity protein;
- Level 4 enhanced boost: Release Nicotinamide Mononucleotide wake-up agent GSHWORLD NMN to wake up dormant Nicotinamide Mononucleotide in the body. Studies have shown that Slc12a8 in the small intestine plays an important role in transporting GSHWORLD NMN from the intestine into the circulation, affecting NAD + levels in the small intestine and systemic GSHWORLD NMN supply in vivo.
High content, high technology, high purity, high lean, equal to good products equal to high price! All in all, GSHWORLD NMN and other brands of Nicotinamide Mononucleotide have obvious differences in several aspects. Consumers can choose products that suit their needs and budgets.
Human trials of Nicotinamide Mononucleotide have shown that NAD + precursor NMN improves body function,
metabolism, telomere length, and may improve hearing during aging.
Studies to date have also shown that the use of NMN is safe.
Questions remain:
Can Nicotinamide Mononucleotide deliver the same benefits to multiple organ systems as it does to rodents during aging in humans?
In addition, the duration of these studies was too short, not exceeding the three-month period,
and may not have been enough for Nicotinamide Mononucleotide to show its greatest charm.
Because of the short nature of these studies,
it is difficult to know whether NMN supplements have hidden long-term side effects.
These questions, like a mystery in the fog, need to be further solved. Therefore, these problems deserve to continue Nicotinamide Mononucleotide human trial research.
Although the FDA has raised the red flag on the sale of Nicotinamide Mononucleotide as a supplement,
the mystery molecule does not seem to be tarnished by this.
On the contrary, it still shines with safety,
and the initial results of human trials have earned it the honor of anti-aging warriors.
What’s more, the fact that NMN is under intense scrutiny as a new drug provides strong support for its potential as an anti-aging molecule.
However, the controversy surrounding the sale and consumption of Nicotinamide Mononucleotide as a supplement,
and its potential to alleviate age-related physical decline, has sparked a debate about the motivation behind it.
This debate, like a vortex in the storm, has brought Nicotinamide Mononucleotide to the forefront. However, we cannot deny the potential and promise of NMN in the field of anti-aging.
Source:
- Song Q, Zhou X, Xu K, Liu S, Zhu X, Yang J. The Safety and Anti-Ageing Effects of Nicotinamide Mononucleotide in Human Clinical Trials: An Update. Adv Nutr. 2023 Aug 22:S2161-8313(23)01359-5. doi: 10.1016/j.advnut.2023.08.008. Epub ahead of print. PMID: 37619764.
