The main effects of glutathione on the skin


glutathione (r-glutamyl cysteingl +glycine, GSH) is a tripeptide containing gamma-amide bond and sulfhydryl group, composed of glutamic acid, cysteine and glycine, which exists in almost every cell of the human body, and has antioxidant and integrated detoxification effects.


Detoxifying glutathione is involved in biotransformation

The thiol group on cysteine the active group of glutathione (so glutathione often abbreviated as G-SH), which easy to combine with some drugs (Glutathione Factory) and toxins (such as free radicals, iodoacetic acid, mustard gas, lead, mercury,

arsenic and other heavy metals), and has an integrated detoxification effect.

Therefore, GSH can participate in the biological transformation,

thereby transforming harmful poisons in the skin into harmless substances and excreting out of the body.

GSH also helps maintain normal immune system function.

Glutathione is involved in biotransformation
GSH is involved in biotransformation

Antioxidant glutathione balances oxidative stress

Glutathione can regulate important metabolic reactions in cells. It is a coenzyme of glyceraldehyde phosphate dehydrogenase and glyoxalase and triose dehydrogenase. It participates in the skin tricarboxylic acid cycle and sugar metabolism, and can activate a variety of enzymes, such as sulfhydryl (SH) enzyme-coenzyme, so as to promote carbohydrate, fat and protein metabolism.

GSH for skin - Balancing oxidative stress
GSH for skin – Balancing oxidative stress

GSH molecule characterized by active sulfhydryl group (-SH), which is the most important functional group. It can participate in a variety of important biochemical reactions in the skin, protect the skin important enzyme protein sulfhydryl group from oxidation and inactivation, and ensure energy metabolism and cell utilization.

At the same time, through the combination of sulfhydryl and free radicals of the skin, it can directly reduce free radicals to acidic substances, thereby accelerating the excretion of free radicals, and combating the damage of free radicals to the skin, so as to achieve the antioxidant effect.

Reference materials:

  • [1] Progress in clinical application of reduced glutathione. China National Knowledge Network. 2014-10-15[Date cited 2019-06-29]
  • [2] Dong Yongsheng. Glutathione production Technology: China Light Industry Press, 2015:274-276
  • [3] Cong Feng Pine. Amazing Small Molecule Active Peptides: Shanghai Jiao Tong University Press, 2015:18