After NMN, What exactly is the 2024 anti-aging supplement, PQQ, AKG, spermidine?

2024 ushered in a new wave of anti-aging ingredients

Led by longevity factor NMN. 2024 ushered in a new wave of anti-aging ingredients. In this paper, we will introduce in detail three of these substances: PQQ (Pyrroloquinoline Quinone Disodium Salt), AKG (alpha-ketoglutaric acid), spermidine, and analyze their research functions and applications.

1. PQQ (pyridoquinone ether)

PQQ is a vitamin-like compound known as the “coenzyme of life”. It mainly plays an antioxidant and anti-inflammatory role by activating mitochondria, improving intracellular energy production. The discovery of PQQ has scientists looking forward to its potential in the field of anti-aging.

The application of PQQ is not limited to anti-aging, or also involves the improvement of cognitive function and the maintenance of cardiovascular health. As a natural substance, it is gradually becoming a high-profile ingredient in health care products.

2. AKG (alpha-ketoglutaric acid)

AKG is a metabolite whose effects include regulation of cellular energy metabolism and enhancement of antioxidant capacity. Although its research is still in its infancy, scientists believe it could have a positive impact on the immune system and cell health.

On September 1, 2020, the Buck Institute for Aging Research, a research institute specializing in aging, published a study on AKG’s anti-aging effects in Cell Metabolism. The paper is titled “Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice.”

The experiment found that AKG can reduce the biological physiological age by an average of 8.5 years, and the maximum can be reduced by 16 years. These findings, based on clinically relevant Healthy lifespan (healthspan) markers, are the first of their kind in a study involving mammals.

The female mice lived an average of 8 to 20 percent longer than the control mice

It is worth noting that the female mice in the experiment lived an average of 8% to 20% longer than the control mice,

which is equivalent to a maximum life extension of 16 years if compared to humans.

Later, Professor Brian Kennedy published another major experimental result in Nature,

which further supported the effect of AKG on human anti-aging.

Rejuvant, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use,in the TruAge DNA methylation test

In the experiment, Professor Kenney’s team organized 42 middle-aged and older people people (average age 63 years) to supplement AKG and vitamin complex preparations for 7 months. After seven months, the researchers re-measured the physiological indicators of the middle-aged and older people.

The results showed that through the 7-month AKG intervention,

the physiological age of this group of middle-aged and older people was 8 years younger on average.

At the same time, the participants’ sleep quality and other indicators also improved,

and their energy levels jumped by about 50 percent.

3. Spermidine

Spermidine is a naturally occurring compound in the human body, which has many health benefits. It can regulate the energy metabolism of cells, enhance the antioxidant defense system, and promote protein synthesis. This makes spermidine become a new substance in the field of anti-aging.

Spermidine widely used in health care products and anti-aging products. In addition to maintaining cell health, spermidine has also been studied to improve athletic performance and boost immune system function.

PQQ, AKG, spermidine as the new anti-aging ingredients in 2024


PQQ, AKG and spermidine, as new anti-aging ingredients in 2024, provide more anti-aging options for humans. Although the study of these substances is still deepening, their potential has aroused widespread interest in the scientific and medical fields.

With the continuous deepening of scientific research,

these emerging ingredients expected to bring more innovation and possibilities to the field of anti-aging.